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ACROBiosystems Mouse Complement Component C5a Protein, His Tag
Marca: ACROBiosystems C5A-M51H4-100ug
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Descripción
Complement Component C5a (C5a) is also known as C5,and is a protein fragment released from complement component C5.,is a potent chemotactic factor for human peripheral blood neutrophils and monocytes, and is believed to play an important role in a number of inflammatory conditions. There are several functions in the below: C5a is an anaphylatoxin, causing the release of histamine from mast cells; C5a is effective leukocyte chemoattractants, causing the accumulation of white blood cells, especially neutrophil granulocytes, at sites of complement activation; C5a activates white blood cells by increasing avidity for white blood cell integrins and upregulating the Lipoxygenase pathway for arachidonic acid metabolism; C5a is a powerful inflammatory mediator, and seems to be a key factor in the development of pathology of many inflammatory diseases involving the complement system; C5a modulates balance between activating versus inhibitory IgG Fc receptors on leukocytes, thereby enhancing autoimmune response.
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 10.9 kDa. The protein migrates as 14 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Especificaciones
| NP_034536.2 | |
| 100 μg | |
| Asn 679 - Arg 755 | |
| C5a,Complement Component 5 A | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 10.9 kDa | |
| Mouse C5a, His Tag (C5A-M51H4) is expressed from E.coli cells. It contains AA Asn 679 - Arg 755 (Accession # P06684). | |
| -20°C | |
| Complement Component C5a | |
| Mouse | |
| PBS, pH7.4 | |
| E.coli | |
| Cytokines and Growth Factors |
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ACROBiosystems Mouse Complement Component C5a Protein, His Tag
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