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IL33 Mouse anti-Human, Clone: 2A9C7, Proteintech
Mouse Monoclonal Antibody
145.00€ - 410.00€
Especificaciones
Antígeno | IL33 |
---|---|
Clon | 2A9C7 |
Concentración | 1.36 mg/mL |
Aplicaciones | Immunocytochemistry, Immunofluorescence, Western Blot, Immunohistochemistry (Paraffin) |
Clasificación | Monoclonal |
Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
---|---|---|---|---|---|---|---|---|---|
Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
16847925
|
Proteintech
66235-1-IG-20UL |
20 μL |
145.00€
20 microlitros |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | |||||
16837925
|
Proteintech
66235-1-IG-150UL |
150 μL |
410.00€
150 microlitros |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | |||||
Descripción
IL-33 (Interleukin-33) is a 270 amino acid, highly divergent protein belonging to the IL-1 family with an IL-1-like C-terminal domain. IL-33 is a dual function protein that may function both as a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. IL-33 binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6. IL-33 activates NF-kappaB and MAP kinases, and drives production of TH2-associated cytokines from in vitro polarized TH2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. IL-33 is proteolytically converted to a mature form by CASP1 and is highly expressed in high endothelial venules found in tonsils, Peyer′s patches and mesenteric lymph nodes and is almost undetectable in placenta. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. Despite its predicted molecular weight, IL-33 will often run at higher molecular weight in SDS-PAGE. Studies have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine, and an intracellular nuclear factor with transcriptional regulatory properties.Especificaciones
IL33 | |
1.36 mg/mL | |
Monoclonal | |
Liquid | |
RUO | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
C9orf26, DVS27, IL 1F11, IL 33, IL1F11, IL33, Interleukin 1 family member 11, interleukin 33, NF HEV, NFEHEV, NFHEV, RP11 575C20.2 | |
IL33 | |
IgM | |
Affinity Chromatography | |
Antibody |
2A9C7 | |
Immunocytochemistry, Immunofluorescence, Western Blot, Immunohistochemistry (Paraffin) | |
Unconjugated | |
Mouse | |
Human | |
O95760 | |
90865 | |
IL33 Fusion Protein Ag21430 | |
Primary | |
-20°C | |
IL33 |
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Título del producto
IL33 Mouse anti-Human, Clone: 2A9C7, Proteintech