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Proteintech™ HumanKine™ Recombinant Human R-Spondin-I Protein
R-Spondin 1 plays several roles in embryonic development including sex phenotype reversal, female sex determination, and ovarian differentiation.
Marca: Proteintech™ HZ-1328-1000UG
Detalles adicionales : Peso : 0.00010kg
Descripción
R-Spondin 1 is an approximately 40kDA, glycosylated protein that serves as a major agonist of the Wnt signaling pathway. It regulates the turnover of the LRP6 co-receptor by preventing its internalization by DKK-1. It also promotes stem cell turnover in the mammary glands, intestine, colon, and kidneys. Increased R-Spondin 1 expression has been linked to growth and migration of ovarian cancer cells as well as decreased sensitivity of gliomas to radiation-based therapies (PMID: 17804805, 22439850, 32749219, 30572097).
Especificaciones
| 284654 | |
| 1000 μg | |
| <1 EU/μg | |
| 40 kDa |
| >95% | |
| Human | |
| Human | |
| Lyophilized |