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STEMCELL Technologies Human Recombinant Fractalkine (CX3CL1)
Fractalkine
Marca: STEMCELL Technologies 78051.1
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Descripción
- Fractalkine (CX3CL1) is a unique chemokine belonging to the CX3C family, and is characterized by a C-X3-C cysteine motif within the chemokine domain, near the amino terminus of the protein
- The chemokine domain is connected to an extended mucin-like stalk, followed by a transmembrane region, and a C-terminal intracellular domain
- The protein signals through interaction with a single receptor, CX3CR1, expressed on monocytes, natural killer cells, T cells, microglia, and smooth muscle cells
- Fractalkine is upregulated in endothelial cells by inflammatory signals and is synthesized as a membrane-bound molecule that mediates cell migration and adhesion
- Cleavage at the base of the stalk by metalloproteinases generates a soluble chemokine, which functions as a potent chemoattractant of target cells
Especificaciones
| C3Xkine, Chemokine (C-X3-C motif) ligand 1, FKN, Neurotactin, NTN, NTT, SCYD1, Small inducible cytokine subfamily D member 1 | |
| 25 μg | |
| Dendritic Cells; Endothelial Cells; Macrophages; Monocytes; NK Cells; T Cells | |
| ≥95% |
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Título del producto
STEMCELL Technologies Human Recombinant Fractalkine (CX3CL1)
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