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Invitrogen™ Rat GM-CSF Recombinant Protein
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Cantidad:
10 μg
100 μg
25 μg
500 μg
Tamaño de la unidad:
10 microgramos
100 microgramos
25 microgramos
500 microgramos
Descripción
GM-CSF (Granulocyte-Macrophage colony-stimulating factor) is a 14.6kDa hematopoietic growth factor that exists in glycosylated and non-glycosylated biologically active forms, and stimulates the development of granulocytes, macrophages, early megakaryocytes and eosinophil progenitor cells. The active form of the GM-CSF protein is found extracellularly as a homodimer and the GM-CSF gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q-syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13. The ability of recombinant GM-CSF to increase hematopoietic cell recovery has become a focus area in the therapeutic treatment of patients following bone marrow transplantation. Recent studies have investigated GM-CSF in inflammatory and autoimmune diseases such as arthritis, arthritis related interstitial lung disease, nephritis, and psoriasis. In the CNS, GM-CSF depletion or neutralization has been studied in experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS).

Especificaciones
Especificaciones
Número de acceso | P48750 |
Concentración | 200 μg/mL |
Para utilizar con (aplicación) | Control, ELISA, Western Blot |
Formulación | PBS with no preservative; pH 7.2 |
ID de gen (Entrez) | 116630 |
Peso molecular | 14.6 kD |
Nombre | Rat GM-CSF (aa 18-144) |
Cantidad | 500 μg |
Fuente | E. coli |
Requisitos de almacenamiento | -20°C |
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