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OCT4 (OCT3) Mouse, anti-Human, PE, Clone: 3A2A20, STEMCELL Technologies
Mouse Monoclonal Antibody
Marca: Stemcell Technologies 60093PE.1
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Descripción
- The 3A2A20 antibody reacts with human OCT4 (octamer-binding transcription factor 4; also known as OCT3 and OCT3/4), an ∼40 kDa homeodomain transcription factor belonging to the POU family, which is expressed in undifferentiated human embryonic stem (ES), induced pluripotent stem (iPS), embryonal carcinoma (EC) and embryonic germ (EG) cells
- OCT4 binds to the octamer motif (5'-ATTTGCAT-3') and plays a key role in maintaining cells in a pluripotent state by interacting with other transcription factors such as SOX2 to regulate the expression of several genes, including FBX15, FGF-4, REX1, SOX2 and osteopontin
- Levels of OCT4 are down-regulated during differentiation and it has thus emerged as a useful marker of pluripotency in stem cells, as well as a marker for certain human malignant germ cell tumours
- Expression of OCT4 together with other transcription factors has been used to reprogram somatic cells into iPS cells
Especificaciones
| OCT4 (OCT3) | |
| Monoclonal | |
| PE | |
| 25 Tests | |
| Human | |
| Pluripotent Stem Cells |
| Flow Cytometry, Western Blot, Immunocytochemistry, Immunofluorescence | |
| 3A2A20 | |
| Mouse | |
| Primary | |
| IgG2b κ |
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Título del producto
OCT4 (OCT3) Mouse, anti-Human, PE, Clone: 3A2A20, STEMCELL Technologies
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