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Gibco™ Human Siglec-2 (CD22) (soluble) Recombinant Protein, PeproTech®
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Cantidad:
1 mg
100 μg
20 μg
250 μg
5 μg
500 μg
Tamaño de la unidad:
1 miligramo
100 microgramos
20 microgramos
250 microgramos
5 microgramos
500 microgramos
Descripción
Recombinant Human CD22 is a soluble 75.0 kDa protein which corresponds to the extracellular domain of CD22. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
CD22 (BL-CAM) is a type 1 integral membrane glycoprotein with molecular weight of 130 to 140 kDa. CD22 is expressed in both the cytoplasm and cell membrane of B-lymphocytes. CD22 antigen appears early in B-cell lymphocyte differentiation at approximately the same stage as the CD19 antigen. Unlike other B-cell markers, CD22 membrane expression is limited to the late differentiation stages comprised between mature B cells (CD22+) and plasma cells (CD22-), and may thus prove useful in phenotyping mature leukemias. CD22 is also strongly expressed in hairy cell leukemia. CD22 preferentially binds to alpha2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B cell antigen receptor signaling. CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. CD22 is also strongly expressed in hairy cell leukemia. CD22 is also positive in diffuse large B-cell lymphoma and nodular lymphocyte predominance Hodgkin’s lymphoma, but negative in classical Hodgkin’s lymphoma.

Especificaciones
Especificaciones
Número de acceso | P20273 |
Para utilizar con (aplicación) | ELISA, Functional Assay, Western Blot |
Formulación | protein with no preservative |
ID de gen (Entrez) | 933 |
Peso molecular | 75 kDa |
Nombre | Human Siglec-2 (CD22) (soluble) |
Cantidad | 5 μg |
Fuente | CHO cells |
Estado normativo | RUO |
Concentración de endotoxinas | <1 EU/ μg |
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Gibco™ Human Siglec-2 (CD22) (soluble) Recombinant Protein, PeproTech® >
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