Invitrogen™ Human PARP14 (aa 1521-1641) Control Fragment Recombinant Protein

Descripción

Highest antigen sequence indentity to the following orthologs: Mouse (56%), Rat (56%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-82454 (PA5-82454. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

Poly [ADP-ribose] polymerase 14 (PARP14) is a B aggressive lymphoma protein belonging to the PARP protein family. Poly ADP ribosylation is a DNA damage dependent post translational modification of histones and other nuclear proteins that mediates DNA repair. PARP proteins with a macrodomain are also involved in gene expression through transcriptional regulation. PARP14 controls STAT6 dependent transcription by enhancing binding to the promoter in the presence of a positive signal (i.e. IL4 stimulation).