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Invitrogen™ Human Factor XI (aa 272-359) Control Fragment Recombinant Protein
Recombinant Protein
Marca: Invitrogen™ RP105968
Descripción
Highest antigen sequence indentity to the following orthologs: Mouse (73%), Rat (73%). This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-111114 (PA5-111114. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.
Especificaciones
P03951 | |
Blocking Assay, Control | |
2160 | |
100 μL | |
1600027G01Rik; AI503996; Cf11; Coagulation factor XI; Coagulation factor XIa heavy chain; Coagulation factor XIa light chain; F11; FXI; LRRGT00086; plasma thromboplastin antecedent; PTA | |
F11 | |
Human | |
His-ABP-tag | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
≥5.0 mg/mL | |
1 M urea, PBS with no preservative; pH 7.4 | |
Human Factor XI (aa 272-359) Control Fragment | |
RUO | |
Factor XI | |
Unconjugated | |
Recombinant | |
SKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQKLCTNAVRCQFFTYTPAQASCNEGKGKCYLKLSSNGSPTKI | |
E. coli | |
>80% by SDS-PAGE and Coomassie blue staining |
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