Invitrogen™ Human CD3 delta Fc Chimera Flag-tag Recombinant Protein

Descripción

It is recommended that the protein be aliquoted for optimal storage. It is recommended that sterile water (1000 μL) be added to the vial to prepare a stock solution of 0.25 mg/mL. Concentration is measured by UV.

CD3d is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The CD3d protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in the CD3d gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms of CD3d have been found. Other variants of CD3d may also exist, but the full-length nature of their transcripts have yet to be defined.