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ACROBiosystems Cynomolgus CD3 epsilon Protein, Fc,His Tag
Brand: ACROBiosystems CDE-C5254-1MG
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Description
CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
This protein carries a human IgG1 Fc tag at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 38.3 kDa. The protein migrates as 43-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Specifications
| 38.3 kDa | |
| Cynomolgus CD3 epsilon, Fc,His Tag (CDE-C5254) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Asp 117 (Accession # Q95LI5). | |
| -20°C | |
| CD3 epsilon | |
| Cynomolgus Monkey | |
| Tris with Glycine, Arginine and NaCl, pH7.5 | |
| HEK293 | |
| Bio-Markers and CD Antigens |
| 1 mg | |
| Gln 22 - Asp 117 | |
| FLJ18683,T3E,TCRE,CD3E,CD3-epsilon | |
| Unconjugated | |
| His Tag and Fc Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
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ACROBiosystems Cynomolgus CD3 epsilon Protein, Fc,His Tag
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