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Invitrogen™ Human CDK4/Cyclin D1, GST Tag Recombinant Protein
Recombinant Protein
690.00€ - 14900.00€
Especificaciones
Número de acceso | P11802 |
---|---|
Concentración | See Label |
Para utilizar con (aplicación) | Kinase Assay |
Formulación | 50 mM tris with 0.02% Triton X-100, 0.5 mM EDTA, 150 mM NaCl, 2 mM DTT, 50% glycerol and no preservative; pH 7.5 |
ID de gen (Entrez) | 1019 |
Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
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Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
11585026
|
Invitrogen™
PV4400 |
10 μg |
690.00€
10 microgramos |
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15427182
|
Invitrogen™
PR8064A |
100 μg |
3250.00€
100 microgramos |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | |||||
10482902
|
Invitrogen™
PV4436 |
1 mg |
14900.00€
1 miligramo |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | |||||
Descripción
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Protein Form: Recombinant, Full Length
CDK4/cyclin D3 serine/threonine kinase is dimeric protein complex. CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle. CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 can mediate phosphorylation of the C-terminal region of Rb protein leading to an active transcriptional repression of E2F complex. CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivity in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein.Especificaciones
P11802 | |
Kinase Assay | |
1019 | |
Human CDK4/Cyclin D1, GST Tag | |
CDK4 | |
Unconjugated | |
Recombinant | |
Full length | |
Ser⁄Thr Kinases: CMCG Group | |
Baculovirus | |
Recombinant, Full Length |
See Label | |
50 mM tris with 0.02% Triton X-100, 0.5 mM EDTA, 150 mM NaCl, 2 mM DTT, 50% glycerol and no preservative; pH 7.5 | |
61.8-61.2 kDa | |
Cdk4; Cell division protein kinase 4; CMM3; Crk3; cyclin dependent kinase 4; cyclin-dependent kinase 4; MGC14458; PSK-J3; serine/threonine kinase; Unknown (protein for MGC:133903) | |
CDK and CHK Kinase Family | |
Human | |
GST-tag | |
-80°C, Avoid Freeze/Thaw Cycles | |
Dry Ice | |
Kinases & Inhibitors | |
Liquid |
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