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CD32 Mouse, anti-Human, FITC, Clone: IV.3, STEMCELL Technologies
Mouse Monoclonal Antibody
Marca: Stemcell Technologies 60012FI.1
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Descripción
- The IV.3 antibody reacts with human CD32 (FcγRII), an ∼40 kDa type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, immunomodulation and platelet aggregation
- CD32 is encoded by three genes (A, B, C) and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc
- All isoforms are expressed by monocytes/macrophages, placental trophoblasts and endothelial cells
- In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells
- Isoform IIc is expressed by NK cells and neutrophils
- CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes
- This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Human T Cell Enrichment Kit (Catalog #19051) and EasySep™ Human CD4+ T Cell Enrichment Kit (Catalog #19052)
Especificaciones
| CD32 | |
| Monoclonal | |
| FITC | |
| 25 Tests | |
| Human | |
| B Cells, Granulocytes and Subsets, Monocytes |
| Blocking Assay, Western Blot, Flow Cytometry, Immunocytochemistry, Functional Assay | |
| IV.3 | |
| Mouse | |
| Primary | |
| IgG2b κ |
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Título del producto
CD32 Mouse, anti-Human, FITC, Clone: IV.3, STEMCELL Technologies
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