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CD32 Mouse, anti-Human, FITC, Clone: IV.3, STEMCELL Technologies
Descripción
- The IV.3 antibody reacts with human CD32 (FcγRII), an ∼40 kDa type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, immunomodulation and platelet aggregation
- CD32 is encoded by three genes (A, B, C) and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc
- All isoforms are expressed by monocytes/macrophages, placental trophoblasts and endothelial cells
- In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells
- Isoform IIc is expressed by NK cells and neutrophils
- CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes
- This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Human T Cell Enrichment Kit (Catalog #19051) and EasySep™ Human CD4+ T Cell Enrichment Kit (Catalog #19052)
Especificaciones
Especificaciones
| Antígeno | CD32 |
| Aplicaciones | Blocking Assay, Western Blot, Flow Cytometry, Immunocytochemistry, Functional Assay |
| Clasificación | Monoclonal |
| Clon | IV.3 |
| Conjugado | FITC |
| Especie del huésped | Mouse |
| Cantidad | 25 Tests |
| Primario o secundario | Primary |
| Especies diana | Human |
| Isotype | IgG2b κ |
| Mostrar más |
Título del producto
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