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WISP1, Rabbit, Polyclonal Antibody, Abnova™
Rabbit polyclonal antibody raised against synthetic peptide of WISP1.
Marca: Abnova PAB4835.400uL
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Descripción
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq
Especificaciones
| WISP1 | |
| Polyclonal | |
| Rabbit polyclonal antibody raised against synthetic peptide of WISP1. | |
| In PBS (0.09% sodium azide) | |
| CCN4/WISP1c/WISP1i/WISP1tc | |
| Rabbit | |
| Protein G purification | |
| RUO | |
| 8840 | |
| Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing. |
| ELISA, Immunohistochemistry (PFA fixed), Western Blot | |
| Unconjugated | |
| ELISA (1:1000) Western Blot (1:100-500) Immunohistochemistry (1:50-100) The optimal working dilution should be determined by the end user. | |
| WISP1 | |
| WISP1 | |
| A synthetic peptide (conjugated with KLH) corresponding to internal region of human WISP1. | |
| 400 μL | |
| Primary | |
| Human | |
| Liquid |
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Título del producto
WISP1, Rabbit, Polyclonal Antibody, Abnova™ > 400μL; Unlabeled
For Research Use Only
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