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ERBB3 Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™
Rabbit polyclonal antibody raised against partial recombinant ERBB3.
Marca: Abnova PAB9951.250ug
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Descripción
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq
Especificaciones
| ERBB3 | |
| Polyclonal | |
| Rabbit polyclonal antibody raised against partial recombinant ERBB3. | |
| In 20mM KH2PO4, 150mM NaCl, pH 7.2 (0.01% sodium azide) | |
| ErbB-3/HER3/LCCS2/MDA-BF-1/MGC88033/c-erbB-3/c-erbB3/erbB3-S/p180-ErbB3/p45-sErbB3/p85-sErbB3 | |
| Rabbit | |
| 250 μg | |
| Primary | |
| Human, Mouse, Rat | |
| Liquid |
| ELISA, Immunoprecipitation, Western Blot | |
| Unconjugated | |
| ELISA (1:10000-1:50000) WB (1:500- 1:2000) Immunoprecipitation (5 ul) The optimal working dilution should be determined by the end user. | |
| ERBB3 | |
| ERBB3 | |
| Recombinant GST fusion protein corresponding to amino acids 1283-1323 of human ERBB3. | |
| RUO | |
| 2065 | |
| Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing. |
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Título del producto
ERBB3 Rabbit anti-Human, Mouse, Rat, Polyclonal Antibody, Abnova™ > 250μg; Unlabeled
For Research Use Only
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