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STEMCELL Technologies Mouse Recombinant IL-4
Interleukin 4
Marca: STEMCELL Technologies 78047.1
Detalles adicionales : Peso : 0.00110kg
Descripción
- Interleukin 4 (IL-4) is a type I cytokine produced by Th2 T cells, NK T cells, γ/δ T cells, eosinophils, mast cells, and activated basophils
- IL-4 receptors are present on a number of cells, including hematopoietic, endothelial, epithelial, muscle, and brain tissues
- IL-4 receptor engagement initiates signaling through the JAK/STAT pathway, and leads to the activation of PI3K and Ras/MAPK pathways (Nelms et al.) IL-4 plays a key role in immunoglobulin class switching in B cells and in regulating the differentiation of naïve T cells into T helper 2 (Th2) cells, while inhibiting Th1 differentiation
- IL-4 acts together with tumor necrosis factor to stimulate expression of adhesion molecules on vascular endothelial cells and to downregulate expression of E-selectin, thus recruiting T cells and eosinophils to the site of inflammation (Nelms et al.)
Especificaciones
| B cell stimulating factor, BCDF, BCGF, BSF-1, Interleukin-4 | |
| 20 μg | |
| B Cells; Dendritic Cells; Hematopoietic Stem and Progenitor Cells; Lymphocytes; Monocytes; Myeloid Cells; Neurons; T Cells | |
| ≥95% |