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STEMCELL Technologies Mouse Recombinant IL-4

Interleukin 4

Marca:  STEMCELL Technologies 78047.1

Detalles adicionales : Peso : 0.00110kg

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Código de producto. 17189431

  • 279.30€ / 20 microgramos
Fecha estimada de envío: 18-11-2022
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Descripción

Descripción

  • Interleukin 4 (IL-4) is a type I cytokine produced by Th2 T cells, NK T cells, γ/δ T cells, eosinophils, mast cells, and activated basophils
  • IL-4 receptors are present on a number of cells, including hematopoietic, endothelial, epithelial, muscle, and brain tissues
  • IL-4 receptor engagement initiates signaling through the JAK/STAT pathway, and leads to the activation of PI3K and Ras/MAPK pathways (Nelms et al.) IL-4 plays a key role in immunoglobulin class switching in B cells and in regulating the differentiation of naïve T cells into T helper 2 (Th2) cells, while inhibiting Th1 differentiation
  • IL-4 acts together with tumor necrosis factor to stimulate expression of adhesion molecules on vascular endothelial cells and to downregulate expression of E-selectin, thus recruiting T cells and eosinophils to the site of inflammation (Nelms et al.)
Especificaciones

Especificaciones

B cell stimulating factor, BCDF, BCGF, BSF-1, Interleukin-4
≥95%
20 μg
B Cells; Dendritic Cells; Hematopoietic Stem and Progenitor Cells; Lymphocytes; Monocytes; Myeloid Cells; Neurons; T Cells
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