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IL-15 Recombinant Rabbit Monoclonal Antibody (112), Invitrogen™
Rabbit Recombinant Monoclonal Antibody
235.00€ - 470.00€
Especificaciones
Antígeno | IL-15 |
---|---|
Clon | 112 |
Concentración | 1 mg/mL |
Aplicaciones | ELISA |
Clasificación | Recombinant Monoclonal |
Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
---|---|---|---|---|---|---|---|---|---|
Código de producto | Marca | Cantidad | Precio | Cantidad y disponibilidad | |||||
17789713
|
Invitrogen
MA543360 |
50 μL |
235.00€
50 microlitros |
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17739663
|
Invitrogen
MA543112 |
100 μL |
470.00€
100 microlitros |
Por favor, inicie sesión para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo. | |||||
Descripción
Specificity: Human IL15/IL-15/Interleukin 15
IL-15 (Interleukin 15 ) is a cytokine that regulates T and natural killer cell activation and proliferation. IL-15 and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. IL-15 induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules. As such, IL-15 could be essential for the immune responses, allograft rejection, and the pathogenesis of autoimmune diseases. Further, IL-15 is a widely expressed pro-inflammatory cytokine and has been shown to play a role in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases. Emerging data suggest that IL-15 may serve as a good therapeutic target, as there appears to be a beneficial effect of IL-15 neutralization in models of psoriasis and diabetes.Especificaciones
IL-15 | |
1 mg/mL | |
Recombinant Monoclonal | |
Liquid | |
RUO | |
PBS with no preservative | |
AI503618; il 15; Il15; IL-15; ILN; Interleukin; interleukin 15; Interleukin15; interleukin-15; MGC9721; M-IL-15 | |
IL15 | |
IgG | |
Protein A | |
Antibody |
112 | |
ELISA | |
Unconjugated | |
Rabbit | |
Human | |
P40933 | |
3600 | |
Recombinant Human IL15/IL-15/Interleukin 15 Protein. | |
Primary | |
-20° C, Avoid Freeze/Thaw Cycles | |
IL15 |