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ACROBiosystems Human Siglec-3 / CD33 Protein, Llama IgG2b Fc Tag, low endotoxin

low endotoxin

423.38€ - 2818.49€

Especificaciones

Número de acceso AAH28152.1
Peso molecular 54.6 kDa
Fuente Human Siglec-3, Llama IgG2b Fc Tag, low endotoxin (CD3-H5259) is expressed from human 293 cells (HEK293). It contains AA Asp 18 - His 259 (Accession # AAH28152.1).
Inmunógeno Asp 18 - His 259
Requisitos de almacenamiento -20°C
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Productos 2
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
15806177
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ACROBiosystems
CD3-H5259-1MG
1 mg
2818.49€
1 miligramo
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Fecha estimada de envío: 21-06-2024
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15896167
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ACROBiosystems
CD3-H5259-100UG
100 μg
423.38€
100 microgramos
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Fecha estimada de envío: 21-06-2024
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Descripción

Descripción

Myeloid cell surface antigen CD33 is also known as SIGLEC3, Siglecs (sialic acid binding Ig­like lectins) and GP67, is a single-pass type I membrane protein which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Human CD33 / Siglec-3 cDNA encodes a 364 amino acid (aa) polypeptide with a hydrophobic signal peptide, an N-­terminal Ig-­like V­-type domain, one Ig­-like C2-­type domains, a transmembrane region and a cytoplasmic tail. CD33 / Siglec-3 usually considered myeloid-specific, but it can also be found on some lymphoid cells. In the immune response, CD33 / Siglec-3 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 / Siglec-3 induces apoptosis in acute myeloid leukemia.

This protein carries a llama IgG2b Fc tag at the C-terminus. The protein has a calculated MW of 54.6 kDa. The protein migrates as 64-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Especificaciones

Especificaciones

AAH28152.1
Human Siglec-3, Llama IgG2b Fc Tag, low endotoxin (CD3-H5259) is expressed from human 293 cells (HEK293). It contains AA Asp 18 - His 259 (Accession # AAH28152.1).
-20°C
Siglec-3
Human
Tris with Glycine, Arginine and NaCl, pH7.5
HEK293
Bio-Markers and CD Antigens
54.6 kDa
Asp 18 - His 259
CD33,SIGLEC3,gp67
Unconjugated
Llama IgG Fc Tag
Less than 0.01 EU / μg by the LAL method.
Powder
>95% as determined by SDS-PAGE
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