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STEMCELL Technologies Human Recombinant IL-2 (E. coli-expressed)
Interleukin 2
Marca: STEMCELL Technologies 78220.1
Detalles adicionales : Peso : 0.00110kg
Descripción
- Interleukin 2 (IL-2) is a monomeric cytokine that was originally identified as a T cell growth factor
- It binds to heterotrimeric receptors consisting of CD25, CD122, and CD132
- Upon binding, it activates JAK3-, STAT5-, and AKT-dependent signaling pathways, which results in cellular proliferation and survival
- The majority of IL-2 is secreted by activated CD4+ and CD8+ T cells, although B cells and dendritic cells were found to produce IL-2 in small amounts
- IL-2 downregulates immune responses to prevent autoimmunity during thymic development, influences the development of CD4+CD25+ T regulatory cells, and affects development of follicular helper T cells
- IL-2 also controls inflammation by inhibiting Th17 differentiation
- Human Recombinant IL-2 has a serine substitute for cysteine at position 126
Especificaciones
| Aldesleukin, Interleukin-2, T cell growth factor, TCGF | |
| 100 μg | |
| Hematopoietic Stem and Progenitor Cells; NK Cells; T Cells; T Cells, CD4+; T Cells, CD8+ | |
| ≥95% |