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STEMCELL Technologies Human Recombinant IL-2 (E. coli-expressed)

Interleukin 2

Marca:  STEMCELL Technologies 78220.3

Detalles adicionales : Peso : 0.00110kg

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Código de producto. 17189881

  • 992.18€ / 1000 microgramos
Fecha estimada de envío: 08-11-2022
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Descripción

Descripción

  • Interleukin 2 (IL-2) is a monomeric cytokine that was originally identified as a T cell growth factor
  • It binds to heterotrimeric receptors consisting of CD25, CD122, and CD132
  • Upon binding, it activates JAK3-, STAT5-, and AKT-dependent signaling pathways, which results in cellular proliferation and survival
  • The majority of IL-2 is secreted by activated CD4+ and CD8+ T cells, although B cells and dendritic cells were found to produce IL-2 in small amounts
  • IL-2 downregulates immune responses to prevent autoimmunity during thymic development, influences the development of CD4+CD25+ T regulatory cells, and affects development of follicular helper T cells
  • IL-2 also controls inflammation by inhibiting Th17 differentiation
  • Human Recombinant IL-2 has a serine substitute for cysteine at position 126
Especificaciones

Especificaciones

Aldesleukin, Interleukin-2, T cell growth factor, TCGF
≥95%
1000 μg
Hematopoietic Stem and Progenitor Cells; NK Cells; T Cells; T Cells, CD4+; T Cells, CD8+
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