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STEMCELL Technologies Human Recombinant IFN-beta
Interferon-beta
Marca: STEMCELL Technologies 78113
Detalles adicionales : Peso : 0.00110kg
Descripción
- Interferon beta (IFN-β), also known as type I interferon, is produced by fibroblasts, and in smaller amounts by plasmocytoid dendritic cells
- Macrophages and endothelial cells secrete IFN-β in response to a viral infection (Reder & Feng)
- IFN-β binds to a receptor complex composed of IFNAR1 and IFNAR2, and initiates signal transduction via the JAK/STAT pathway; this culminates in the transcription and activation of many genes that control dendritic cell activation, T cell survival, NK cell activation, chemokine expression, lymph node retention, and antiproliferative and antiviral effects (Dunn et al.) IFN-β is a first-line treatment for multiple sclerosis
- It suppresses Th17 cells by affecting expression of IL-4, IL-10, and IL-27
- IFN-β was also shown to expand regulatory T cells and limit T cell trafficking to the central nervous system (Inoue & Shinohara)
- Out of the two variants of IFN-β (IFN-β1 and IFN-β3), this product is the IFN-β1 form
Especificaciones
| B cell interferon, Fibroblast interferon, IFNB1, Leukocyte interferon, Type I interferon | |
| 5 μg | |
| B Cells; Cancer Cells and Cell Lines; NK Cells; T Cells | |
| ≥95% |