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ACROBiosystems Human PCSK9 Protein, His Tag
Brand: ACROBiosystems PC9-H5223-50UG
Additional Details : Peso : 0.00001kg
Description
Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
This protein carries a polyhistidine tag at the C-terminus. This protein undergoes autocatalytic cleavage to release the pro-peptide and mature chain. The pro-peptide and mature chain are associated through non‐covalent interactions and with a calculatedSpecifications
| AAI66619.1 | |
| 50 μg | |
| Gln 31 - Gln 692 | |
| PCSK9,FH3,HCHOLA3,LDLCQ1,NARC1,PC9 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >97% as determined by SDS-PAGE |
| 13.8 kDa and 58.1 kDa | |
| Human PCSK9, His Tag (PC9-H5223) is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Gln 692 (Accession # Q8NBP7-1). | |
| -20°C | |
| PCSK9 | |
| Human | |
| PBS, pH7.4 | |
| HEK293 | |
| Bio-Markers and CD Antigens |