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ACROBiosystems Human Flt-3 / Flk-2 Protein, Fc Tag

Marca:  ACROBiosystems FL3-H5258-100ug

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 16477539

  • 335.29€ / 100 microgramos
Fecha estimada de envío: 05-08-2022
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Descripción

Descripción

Flt-3(Receptor-type tyrosine-protein kinase FLT3) is also known as FLK-2(Fetal liver kinase-2), STK-1(Stem cell tyrosine kinase 1), CD135. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 84.8 kDa. The protein migrates as 110-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Especificaciones

Especificaciones

NP_004110.2
84.8 kDa
100 µg
Asn 27 - Ser 543
Flt-3,Flk-2,STK-1,CD135,FLK2,FLT-3
Unconjugated
Tris with Glycine, Arginine and NaCl, pH7.5
HEK293
Human
Powder
>95% as determined by SDS-PAGE
Human Flt-3, Fc Tag (FL3-H5258) is expressed from human 293 cells (HEK293). It contains AA Asn 27 - Ser 543 (Accession # P36888-1).
-20°C
Flt-3
Fc Tag
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
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SDS
Documentos
Certificados
Ofertas especiales

Ofertas especiales