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ACROBiosystems Human CD27 Ligand / CD70 Protein, Fc Tag (active trimer)

MALS verified

Marca:  ACROBiosystems CDL-H5266-1mg

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 17196231

  • 2896.79€ / 1 miligramo
Fecha estimada de envío: 14-10-2022
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Descripción

Descripción

Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.

This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 74.1 kDa. The protein migrates as 130-150 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
Especificaciones

Especificaciones

NP_001243.1
74.1 kDa
1 mg
Ser 52 - Pro 193
CD70,CD27LG,TNFSF7,TNFSF7G,CD27L
Unconjugated
Tris, Glycine and NaCl, pH7.5
HEK293
Human
Powder
>95% as determined by SDS-PAGE
Human CD27 Ligand, Fc Tag (active trimer) (MALS verified) (CDL-H5266) is expressed from human 293 cells (HEK293). It contains AA Ser 52 - Pro 193 (Accession # P32970-1) trimer Design.
-20°C
CD27 Ligand
Fc Tag
Less than 1.0 EU / µg by the LAL method.
Immune Checkpoint Proteins
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