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ACROBiosystems Cynomolgus LILRB4 / CD85k / ILT3 Protein, Fc Tag

Marca:  ACROBiosystems CDK-C5258-1mg

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 16477379

  • 2794.06€ / 1 miligramo
Fecha estimada de envío: 04-08-2022
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Descripción

Descripción

Leukocyte immunoglobulin-like receptor subfamily B member 4 (LILRB4) is also known as CD85 antigen-like family member K (CD85K), Immunoglobulin-like transcript 3 (ILT-3), Leukocyte immunoglobulin-like receptor 5 (LIR-5), Monocyte inhibitory receptor HM18, which belongs to the leukocyte immunoglobulin-like receptor (LIR) family. LILRB4 / CD85K contains 2 Ig-like C2-type (immunoglobulin-like) domains. CD85K is detected in monocytes, macrophages, dendritic cells, lung, natural killer cells and B-cells. LILRB4 / CD85K is receptor for class I MHC antigens. CD85K recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles, involved in the down-regulation of the immune response and the development of tolerance. LILRB4 interferes with TNFRSF5-signaling and NF-kappa-B up-regulation and inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 52.7 kDa. As a result of glycosylation, the protein migrates as 60-66 kDa under reducing (R) condition, and 120-140 kDa under non-reducing (NR) condition (SDS-P
Especificaciones

Especificaciones

XP_015297198.1
52.7 kDa
1 mg
Gln 22 - Glu 259
LILRB4,ILT3,LIR5,CD85K,HM18
Unconjugated
Tris with Glycine, Arginine and NaCl, pH7.5
HEK293
Cynomolgus
Powder
>85% as determined by SDS-PAGE
Cynomolgus LILRB4, Fc Tag (CDK-C5258) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Glu 259 (Accession # XP_015297198.1).
-20°C
LILRB4
Fc Tag
Less than 1.0 EU / µg by the LAL method.
Immune Checkpoint Proteins
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