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ACROBiosystems Cynomolgus GUCY2C / Guanylyl cyclase C Protein, His Tag

Marca:  ACROBiosystems GUC-C52H6-1mg

Detalles adicionales : Peso : 0.00010kg

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Código de producto. 17186341

  • 2896.79€ / 1 miligramo
Fecha estimada de envío: 22-12-2022
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Descripción

Descripción

GUCY2C (Guanylyl Cyclase C), also known as heat-stable enterotoxin receptor, is a type I transmembrane protein of the guanylate cyclase (gc) family that signal by producing cGMP. Guanylate cyclase C (GUCY2C) and its hormones guanylin and uroguanylin have recently emerged as one paracrine axis defending intestinal mucosal integrity against mutational, chemical, and inflammatory injury. GUCY2C murine CAR-T cells recognized and killed human colorectal cancer cells endogenously expressing GUCY2C. Thus, we have identified a human GUCY2C-specific CAR-T cell therapy approach that may be developed for the treatment of GUCY2C-expressing metastatic colorectal cancer.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 48.0 kDa. The protein migrates as 60-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Especificaciones

Especificaciones

XP_005570270.1
48.0 kDa
1 mg
Ser 24 - Gln 430
GUCY2C,GUC2C,STAR,STA receptor,hSTAR,GC-C
Unconjugated
PBS, pH7.4
HEK293
Cynomolgus
Powder
>90% as determined by SDS-PAGE
Cynomolgus GUCY2C, His Tag (GUC-C52H6) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Gln 430 (Accession # XP_005570270.1).
-20°C
GUCY2C
His Tag
Less than 1.0 EU / µg by the LAL method.
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