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BCR Mouse anti-Human, Clone:1E11G12, Abnova™
Mouse monoclonal antibody raised against partial recombinant human BCR.
Marca: Abnova MAB17933.100ug
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Descripción
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]Especificaciones
| BCR | |
| Monoclonal | |
| Unconjugated | |
| ELISA (1:10000) Flow Cytometry (1:200-1:400) Western Blot (1:100-1:500) The optimal working dilution should be determined by the end user. |
|
| BCR | |
| Mouse | |
| 100 μg | |
| Human | |
| Antibody | |
| IgG1 |
| ELISA, Flow Cytometry, Western Blot | |
| 1E11G12 | |
| breakpoint cluster region | |
| In PBS (0.05% sodium azide) | |
| ALL, BCR-ABL1, BCR1, CML, D22S11, D22S662, FLJ16453, PHL | |
| Recombinant protein corresponding to amino acids 139-280 of human BCR. | |
| 613 | |
| Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing. |
|
| Liquid |
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Título del producto
BCR Mouse anti-Human, Clone:1E11G12, Abnova™ > 100μg
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