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Ronin/THAP11 Mouse, Unlabeled, Clone: P56-507, BD
Mouse Monoclonal Antibody
Marca: BD Biosciences 562548
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Descripción
Thanatos-associated proteins (THAPs) are characterized by the THAP domain, which is a conserved Drosophila P element transposase DNA-binding domain. THAPs are DNA-binding factors involved in cell proliferation, apoptosis, cell cycle and transcriptional regulation. THAP11 is an essential factor in embryogenesis and ES cell pluripotency and binds directly to host cell factor 1 (HCF-1), a key regulator of transcriptional control. THAP11 has been designated as Ronin, named for a masterless Japanese samurai because of its lack of any apparent relationship to Nanog, Oct4 and Sox2–the master regulators of pluripotency. Ronin/THAP11 binds to the c-Myc promoter and down-regulates c-Myc expression. Recently, it was reported that Bcr-Abl inhibited the expression of THAP11 in Chronic myelogenous leukemia (CML) cells and promoted CML cell proliferation by the aberrant induction of c-Myc expression.
Host Species: Mouse
Clone: P56-507
Isotype: IgG2b, κ
Species Reactivity: Human
Immunogen: Human Ronin/THAP11 Recombinant Protein
Western Blotting
Especificaciones
| Ronin/THAP11 | |
| Monoclonal | |
| 0.5mg/mL | |
| Ronin, THAP11 | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Human, Mouse | |
| IgG2b κ |
| Western Blot | |
| P56-507 | |
| Unconjugated | |
| Aqueous buffered solution containing ≤0.09% sodium azide. | |
| Human Ronin/THAP11 Recombinant Protein | |
| 0.1 mg | |
| Primary | |
| Store undiluted at 4°C |
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Título del producto
Ronin/THAP11 Mouse, Unlabeled, Clone: P56-507, BD > 0.1mg; Unlabeled
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