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Occludin Mouse, Unlabeled, Clone: 19, BD

Mouse Monoclonal Antibody

343.00€ - 675.00€

Especificaciones

Antígeno Occludin
Clon 19
Concentración 250μg/mL
Aplicaciones Western Blot
Clasificación Monoclonal
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Productos 2
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
Código de producto Marca Cantidad Precio Cantidad y disponibilidad  
15865789
Ver documentos Detalles de la promoción
BD Biosciences
611090
50 μg
343.00€
1 set
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Fecha estimada de envío: 22-04-2024
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15875789
Ver documentos Detalles de la promoción
BD Biosciences
611091
150 μg
675.00€
1 set
Ver productos alternativos
Ahorre hasta 
»
Fecha estimada de envío: 22-04-2024
para ver el stock
Por favor, para comprar este producto. ¿No tiene usuario web? Regístrese hoy mismo.
Descripción

Descripción

Tight junctions (zonulae occludens) are critical to the maintenance of cell polarity and intercellular barriers between epithelial and endothelial cells. Among the barriers formed by the tight junctions is the critical blood-brain barrier. Protein components of the tight junctions include actin filaments, symplekin, occludin, Rab3B, AF-6, 7H6, ZO-1 and ZO-2. The human occludin protein is 522 amino acids with four transmembrane domains in the first half of the protein. Two glycine/tyrosine-rich extracellular loops are involved in cell-cell interactions. In the cytoplasm, occludin interacts with ZO-1 through its intracellular C-terminus. A possible function of ZO-1 may be to link the adherens components, like occludin, to the submembraneous actin cytoskeleton. Experimental breakdown of the tight junctions at the blood-brain barrier results in redistribution of vinculin and loss of ZO-1 and Occludin. Taken together, these data indicate that occludin and ZO-1 are critical elements in the formation of tight junctions and may also serve an important role in signaling and tumor suppression.
Especificaciones

Especificaciones

Occludin
250μg/mL
Monoclonal
Mouse
Cell Biology
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
IgG1
Affinity Purified
19
Western Blot
Unconjugated
RUO
Canine, Human, Mouse, Rat
Mouse Occludin aa. 396-507
Primary
Store undiluted at -20°C.
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For Research Use Only.