anti-CTLA-4/CD152 PE, Clone: UC10-4F10-11, Invitrogen™

Descripción

CTLA-4/CD152 Monoclonal antibody A18686 from Invitrogen specifically detects CTLA-4/CD152 in Mouse samples. It is validated for Flow Cytometry.

CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) is a CD28-family receptor expressed on mainly CD4+ T cells. It binds the same ligands as CD28 (CD80 and CD86 on B cells and dendritic cells), but with higher affinity than CD28. However, in contrast to CD28 which enhances cell function when bound at the same time as the T cell receptor, CTLA4 inhbits the T cell and prevents it from functioning. Intracellular CTLA4 is also found in regulatory T cells and may be important to their function.
Host Species: Hamster
Cross Reactivity: Mouse
Isotype: IgG1, κ
Clone: UC10-4F10-11
Immunogen: Mouse CD152
Formulation: 25μg Purified Antibody (0.2mg/ml) in PBS, with 0.1% gelatin and 0.09% sodium azide; pH7.2
Synonyms: CELIAC3, CTLA-4, GRD4, GSE, ICOS, IDDM12, CD152 isoform, celiac disease 3, cytotoxic T lymphocyte associated antigen 4 short spliced form, cytotoxic T-lymphocyte antigen 4
Uniprot Accession: P09793
Entrez GeneID: 12477
Gene Symbol: Ctla4
This product detects CTLA-4/CD152 in Mouse samples. This product has been successfully used in Flow Cytometry procedures. The immunogen is Mouse CD152.