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CD61 Mouse anti-Human, Unlabeled, Clone: 1, BD

Mouse Monoclonal Antibody

241.00€ - 416.80€

Especificaciones

Antígeno CD61
Isotipo IgG1
Inmunógeno Human Integrin β3 aa. 592-712
Formulación Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugado Unconjugated
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Productos 2
Código de producto Marca Cantidad. Precio Cantidad y disponibilidad  
Código de producto Marca Cantidad. Precio Cantidad y disponibilidad  
15825819 Ver documentos BD Biosciences
611140
50μg 241.00€
cada uno Ver productos alternativos
Ahorre hasta 
»
Fecha estimada de envío
11-10-2019
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15835819 Ver documentos BD Biosciences
611141
150μg 416.80€
cada uno Ver productos alternativos
Ahorre hasta 
»
Fecha estimada de envío
11-10-2019
Añadir a la cesta
 
Descripción

Descripción

Integrins are heterodimeric transmembrane receptors that mediate cell-cell or cell-matrix adhesion. They contain noncovalently associated α and β subunits that consist of a large extracellular region (the ligand-binding domain), a short transmembrane region, and a cytoplasmic domain of varying length. In mammals, at least 17 α subunits and 8 β subunits have been identified and these proteins can heterodimerize to form at least 22 different receptors. Although there is a high degree of redunancy, each integrin has a specific biological function. For example, the β3 subunit associates with αIIb in platelets where this glycoprotein complex acts as a fibrinogen receptor and mediates platelet aggregation. In endothelial cells (EC), β3 complexes with the αv subunit to form the vitronectin receptor. This receptor mediates endothelial cell adhesion to vitronectin, fibrinogen, von Willebrand factor, thrombospondin, laminin, and fibronectin. In confluent EC cultures, the αvβ3 integrin localizes to focal adhesions at the cell body and cell-cell borders. Thus, continued study of individual integrin subunits will provide insights to mechanisms of cell adhesion and signaling.

Host Species: Mouse
Clone: 1
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Integrin β3 aa. 592-712
Formula Weight [Chemical]: 104kDa

Immunofluorescence, Western Blotting

Especificaciones

Especificaciones

CD61
Human Integrin β3 aa. 592-712
Unconjugated
Cell Biology
Murine
Affinity Purified
Monoclonal
Integrin β3 chain
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
1
250μg/mL
Store undiluted at -20°C.

For Research Use Only.