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CD54 (ICAM-1) Mouse anti-Human, Unlabeled, Clone: 28, BD
Mouse Monoclonal Antibody
Marca: BD Biosciences 611704
255.80 EUR hasta el 2025-12-31
Use el código promocional "25339" para aplicar la oferta.
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Descripción
The migration of T cells through lymph nodes and their interactions with antigen presenting cells (APCs) involve adhesion molecules on the surfaces of the T cell and the cell with which it interacts. These molecules include the selectins, the integrins, members of the immunoglobulin superfamily, and some mucin-like proteins. The integrins mediate adhesion between cells and between cells and the extracellular matrix. LFA-1 (lymphocyte function-associated antigen 1), a member of the β2 integrin family, is expressed on T cells, neutrophils, and macrophages and is thought to be the most important adhesion molecule for lymphocyte activation. It interacts with members of the immunoglobulin superfamily, the intercellular adhesion molecules: ICAM-1, -2, and -3. ICAM-1 and ICAM-2 are expressed on endodthelium and APCs, while ICAM-3 is expressed only on leukocytes. ICAM-1 is most homologous to neural cell adhesion molecule and myelin-associated glycoprotein. It is a 55kDa glycoprotein that is heavily glycosylated to form 90kDa to 115kDa proteins. Its interactions with LFA-1 are necessary for CTL and NK mediated killing, T and B cell responses, and immune cell extravasation.
Host Species: Mouse
Clone: 28
Isotype: IgG1
Species Reactivity [for Features Main]: Human
Immunogen: Human CD54/ICAM-1 aa. 46-160
Immunofluorescence, Western Blotting
Especificaciones
| CD54 | |
| Monoclonal | |
| 250μg/mL | |
| ICAM-1 | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at -20°C. |
| Western Blot | |
| 28 | |
| Unconjugated | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| Human CD54/ICAM-1 aa. 46-160 | |
| 50 μg | |
| Immunology | |
| Human | |
| IgG1 |
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Título del producto
CD54 (ICAM-1) Mouse anti-Human, Unlabeled, Clone: 28, BD > 50μg; Unlabeled
For Research Use Only.
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