anti-c-Kit/CD117 APC, Clone: ACK2, Invitrogen™

Descripción

c-Kit/CD117 Monoclonal antibody A27052 from Invitrogen specifically detects c-Kit/CD117 in Mouse samples. It is validated for Flow Cytometry.

c-Kit, also known as CD117 and stem cell factor receptor, is a 145 kDa transmembrane tyrosine kinase encoded by the c-Kit proto-oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. c-Kit mutations correlate with tumor growth and progression in a variety of cancers including mast cell disease, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma, and lung cancer. Phosphorylation at tyrosine 703 of c-Kit allows binding of Grb2 and activation of the Ras-Raf-ERK1&2 signaling pathway.
Host Species: Rat
Cross Reactivity: Mouse
Isotype: IgG2b, κ
Clone: ACK2
Immunogen: Mouse CD117
Formulation: 100μg Purified Antibody in PBS, with 0.1% gelatin and 0.09% sodium azide
Synonyms: C-Kit, CD117, PBT, SCFR, mast/stem cell growth factor receptor Kit, p145 c-kit, piebald trait protein, proto-oncogene c-Kit, proto-oncogene tyrosine-protein kinase Kit, soluble KIT variant 1, tyrosine-protein kinase Kit, v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
Uniprot Accession: P05532
Entrez GeneID: 16590
Gene Symbol: Kit
Allophycocyanin (APC) is a stable and highly soluble phycobiliprotein that provides maximal absorbance and fluorescence without susceptibility to internal or external fluorescence quenching, thus providing exceptional quantum yields and molar extinction coefficients.