The sorting of acid hydrolases to lysosomes rely on mannose 6-phosphate receptors that cycle between the trans-Golgi network (TGN) and endosomes. The maintece of this cycle requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex which is composed of three subunits: VPS52, VPS53, and VPS54. Depletion of any of these three proteins, such as by RNAi, impairs the retrograde transport of multiple TGN proteins. VPS53 was identified as an HIV dependency factor (HDF) and plays a role in viral entry to the cell, suggesting that VPS53 may be an important drug target in ...
Cat # 12888722
100 µg
Cat # 12878722
100 µg
Cat # 16191429
50 µg
Cat # 16000707
100 ug
Cat # 16820744
150 µL
Cat # 15793001
100 µL
Cat # 16010707
100 ug
Cat # 15702591
100 µL
Cat # 16830744
20 µL
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