This gene belongs to a group of vacuolar protein sorting genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms.
hVPS26; vacuolar protein sorting 26 homolog A; Vacuolar protein sorting-associated protein 26A; Vesicle protein sorting 26A; VPS26 retromer complex comonent A; VPS26 retromer complex component A; VPS26A vacuolar protein sorting 26 homologue A (yeast) FLJ12930 HB58 Hbeta58 VPS26 Hbeta58 homolog vacuolar protein sorting 26 (yeast homolog) vacuolar protein sorting 26 (yeast) vacuolar protein sorting 26 homolog A vacuolar protein sorting 26 homolog A (S. pombe) PEP8A OTTHUMP00000019721 vacuolar protein sorting 26 A
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