TCF7 (transcriptional factor 7) is a transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4+ and CD8+ immature thymocytes. Isoforms for TCF7 lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. TCF7 binds to the T-lymphocyte-specific enhancer element (5′-WWCAAAG-3′) found in the promoter of the CD3E gene. It may also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3, and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
T-cell factor 1; T-cell-specific transcription factor 1; T-cell-specific transcription factor 1 T-cell factor 1 Transcription factor 7 TCF7 TCF-7 TCF-1 TCF1; TCF-7; Transcription factor 7
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100 µg
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100 µl
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20 µL
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400 uL
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150 µL
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50 uL
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100 µg
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100 µL
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100 µL
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100 µL
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100 µg
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100 uL
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