Probable GTPase-activating protein for Rab8; its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor (TfR) and reduces Rab8 recruitment to tubules emanating from the endocytic recycling compartment (ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50; the function requires its catalytic activity, however, the involved Rab is not known.
TBC1 domain family member 17; TBC1 domain family member 17 TBC1 domain family member 17 TBC1D17; TBC1 domain family, member 17
Cat # 16870025
20 µL
Cat # 15879343
100 µL
Cat # 16860025
150 µL
Cat # 15772122
100 µL
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