Polytopic transmembrane protein that inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis (PubMed:25310401, PubMed:27499293). In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1 (PubMed:27499293). Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called ′regulated alternative translocation′ (RAT) and regulates the function of the transmembrane protein (PubMed:27499293).
PRO994 TCCE518 transmembrane 4 L6 family member 20; transmembrane 4 L six family member 20; Transmembrane 4 L6 family member 20
Cat # 15858053
100 µL
Cat # 15751862
100 µL
Cat # 15939464
100 µL
Cat # 15720292
100 µL
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