Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin (PubMed:26109053). Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription (PubMed:26109053). Binds DNA and histones and promotes nucleosome assembly (in vitro) (PubMed:23378026, PubMed:26109053). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (PubMed:26109053). Modulates RNA polymerase 1-mediated transcription. Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (PubMed:23378026).
Protein KU002155; Protein SPT2 homolog; SPT2 domain-containing protein 1; Spt2 protein SPT2 homolog SPT2 domain-containing protein 1 SPT2 Suppressor of Ty domain containing 1; SPT2, Suppressor of Ty, domain containing 1
Cat # 15918234
100 µL
Cat # 15776631
100 µL
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