The ring finger protein RC3H1, also known as Roquin, is a highly conserved member of the RING type ubiquitin ligase protein family whose M199R mutation leads to the excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, a strain with excessive IL-21 production and high titers of autoantibodies. The complete loss of RC3H1 induces early death and immune deregulation but not autoimmunity in RC3H1-null mice, suggesting that the mutant RC3H1 is more disruptive to the immune system than its complete loss.
probable E3 ubiquitin-protein ligase Roquin; RC3H1 Ring finger and CCCH-type domains 1 ring finger protein 198 RNF198 roquin; RING finger and C3H zinc finger protein 1; RING finger and CCCH-type zinc finger domain-containing protein 1; RING finger protein 198; Roquin; Roquin-1
Cat # 15783531
100 µL
Cat # 16322535
100 µL
Cat # 15753541
100 µL
Cat # 16134840
100 uL
Cat # 16114830
100 uL
Cat # 15753531
100 µL
Cat # 16104830
100 uL
Cat # 16027447
100 ug
Cat # 15395441
100 µg
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