This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.
Ca2+-promoted Ras inactivator; Calcium-promoted Ras inactivator; CAPRI GAPL Ca2+-promoted Ras inactivator calcium-promoted Ras inactivator ras GTPase-activating protein 4 rasGAP-activating-like protein 2; Ras GTPase-activating protein 4; Ras p21 protein activator 4; RasGAP-activating-like protein 2
Cat # 15768031
100 µL
Cat # 17148203
100 µL
Cat # 13436457
100 µL
Cat # 17288603
100 µL
Cat # 15684705
100 µL
Cat # 13446407
100 µL
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