Cyclic nucleotide phosphodiesterases (PDEs) catalyze hydrolysis of the 5-prime,3-prime-cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been grouped into several families based on substrate affinities, inhibitor sensitivities, mode of regulation, and amino acid sequence homologies. The PDE8 family contains high-affinity cAMP-specific, IBMX (3-isobutyl-1-methyl-xanthine)-insensitive PDEs, such as PDE8B. All PDEs share a conserved C-terminal catalytic region and a variable N-terminal domain that presumably accounts for the distinctive regulatory properties unique to the individual families.
3',5' cyclic nucleotide phosphodiesterase 8B; cAMP-specific cyclic nucleotide phosphodiesterase PDE8; Cell proliferation-inducing gene 22 protein; FLJ11212 PPNAD3; High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B; HsPDE8B
Cat # 11571623
100 µg
Cat # 16032077
50 ug
Cat # 16042077
50 ug
Cat # 13454649
50 µg
Cat # 16300325
100 µL
Cat # 13474649
50 µg
Cat # 15987944
100 µL
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