This gene is a member of the type IV, cyclic AMP family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
cAMP-specific 3',5'-cyclic phosphodiesterase 4B; DPDE4; dunce-like phosphodiesterase E4; PDE32; PDE4B phosphodiesterase 4B cAMP-specific (phosphodiesterase E4 dunce homolog Drosophila) RP5-876C12.1 DKFZp686F2182 DPDE4 MGC126529 PDEIVB OTTHUMP00000046896 cAMP-specific 3&prime5&prime-cyclic phosphodiesterase 4B dunce-like phosphodiesterase E4 phosphodiesterase 4B cAMP-specific phosphodiesterase 4B cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E4); phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
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100 µL
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100 µL
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100 µL
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