Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.
ABRI BRI BRI2 BRICD2B E25B E3-16 FBD ABri/ADan amyloid peptide BRICHOS domain containing 2B transmembrane protein BRI; ABri/ADan amyloid peptide; ABri23; Bri; BRI2 ICD; BRI2 intracellular domain; BRI2, membrane form; Bri2-23; Bri23 peptide; BRI2C, soluble form; BRICHOS domain containing 2B; C-terminal peptide; imBRI2; Immature BRI2; Integral membrane protein 2B; Integral membrane protein 2B (E25B protein); Mature BRI2; mBRI2; P23 peptide; Protein E25B; Transmembrane protein BRI
Cat # 13435967
100 µL
Cat # 13429964
100 ug
Cat # 11327053
100 µg
Cat # 15999884
100 µL
Cat # 16180646
50 µg
Cat # 16100656
100 ug
Cat # 16190646
50 ug
Cat # 15965114
100 µL
Cat # 16110656
100 ug
Cat # 16380035
100 µL
Cat # 16071637
100 ug
Cat # 15779362
25 ug
Searching for an antibody we don't offer? We make custom antibodies for specific targets, species and applications.
More than 18,000 custom antibodies created so far.
Talk To A Specialist NowIf an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.