IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. ...
Cat # 16391385
100 µL
Cat # 15755346
0.1 ml
Cat # 15898704
100 µg
Cat # 16107610
100 uL
Cat # 16109854
50 µg
Cat # 15525702
100 µL
Cat # 16119854
100 µL
Cat # 13453687
100 µL
Cat # 16577421
100 µL
Cat # 16139854
100 µg
Cat # 13259528
100 µL
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100 µL
Cat # 16824284
150 µL
Cat # 16540682
100 µg
Cat # 15729565
0.1 ml
Cat # 16834284
20 µL
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