This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.
BTB (POZ) domain containing 12; BTB/POZ domain-containing protein 12; SLX4 structure-specific endonuclease subunit homolog; SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) KIAA1784 KIAA1987 MUS312 SLX4 FANCP BTBD12; Structure-specific endonuclease subunit SLX4
Cat # 15516782
100 µL
Cat # 15765797
0.1 mg
Cat # 15782032
100 µL
Cat # 15918304
100 µL
Cat # 16124799
50 µg
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