BRD7 acts both as coactivator and as corepressor. For example, it activates the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. In addition, it is required for TP53-mediated cell-cycle arrest in response to oncogene activation. BRD7 promotes acetylation of TP53 at Lys-382, and thereby promotes efficient recruitment of TP53 to target promoters, inhibiting cell cycle progression from G1 to S phase.
75 kDa bromodomain protein; 75 kDa bromodomain protein BP75 BRD7 bromodomain containing 7 CELTIX1 NAG4 Protein CELTIX 1; bromodomain protein 75 kDa; bromodomain-containing 7; Bromodomain-containing protein 7; Protein CELTIX-1; protein tyrosine phosphatase, non-receptor type 13 interacting protein
Cat # 16836265
150 µL
Cat # 16146026
50 ug
Cat # 15534872
100 µL
Cat # 16598941
100 µL
Cat # 15904465
100 µg
Cat # 16846265
20 µL
Cat # 15987364
400 µL
Cat # 16397174
100 µl
Cat # 16676494
100 µL
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