BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. ...
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100 µg
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500 µL
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150 µL
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100 µL
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100 µL
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100 µL
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100 µL
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0.1 ml
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20 µL
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100 µg
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1 mL
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1 mL
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20 µL
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150 µL
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1 mL
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0.1 ml
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100 µg
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0.05 mg
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100 µL
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