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Invitrogen™ Human TLK1, GST Tag Recombinant Protein
TLK1 or tousled-like kinase 1 is a nuclear serine/threonine kinase that is potentially involved in the regulation of chromatin assembly. Recombinant full-length human TLK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Marca: Invitrogen™ PV6421
Detalles adicionales : Peso : 0.01000kg
Descripción
TLK1 is first described in Arabidopsis. TLK1 is a novel target of the DNA damage checkpoint that is rapidly inactivated upon exposure to ionizing radiation (IR) and the inactivation is directly mediated by the S-phase DNA damage checkpoint. The suppression of TLK1 activity after double-strand breaks in the DNA, replication blockade, or low doses of ultraviolet irradiation requires ATM, NBS and CHK1.
- Validated in LanthaScreen™ Kinase Binding Assay
- Protocols available for simple use and optimized performance
- Multiple pack sizes available for convenient use
Especificaciones
| Kinase Assay | |
| 10μg | |
| Human | |
| GST Tag | |
| Biochemical binding/kinetic | |
| TLK1 | |
| Kinases & Inhibitors | |
| Liquid |
| 113.0 kDa | |
| KIAA0137, PKU-beta | |
| Recombinant | |
| Storage Buffer: 50 mM Tris-HCl pH 7.5, 150 mM NaCl, 0.25 mM DTT, 10 mM glutathione, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol Store at -68 to -85°C. Aliquot at first use to avoid multiple freeze-thaws. |
|
| Serine/Threonine Kinase | |
| Baculovirus | |
| Recombinant, Full Length | |
| Serine/Threonine Kinases |